AMD is a disease in which the structure of photoreceptor cells in the macula degenerates with aging. In the case of wet-AMD,
the damaged choroidal structure forms new blood vessels (angiogenesis) and disease progresses quickly.
Cause
The main causes of retinal pigment epithelial (RPE) damage are inflammation and oxidative stress induced by free radicals. HSG4112 has the effect of reducing the generation of free radicals and inflammation by restoring mitochondrial function.
HSG4112
The main treatment for wet-AMD, which is anti-VEGF (angiogenesis inhibitor) therapy, has its drawbacks: direct injection into the eye is burdensome and there are numerous non-responders to the therapy. HSG4112 is an easy-to-take oral tablet and can be the ultimate treatment of AMD by reducing chronic inflammation.
Retinitis pigmentosa (RP)
Retinitis pigmentosa (RP)
Retinitis pigmentosa (RP)
Retinitis pigmentosa (RP) is a rare hereditary and progressive disease in which retinal function is gradually lost and can lead to blindness. A genetic mutation of rhodopsin in the photoreceptor is pointed out as the main cause, and it is reported to occur in 1 out of 4000 people. There is no cure for RP yet, and RP causes considerable inconvenience in daily life due to night blindness and narrowing of the field of view. Oxidative stress in the retina has also been reported in RP. Research on whether Glaceum's drug has an anti-inflammatory and anti-oxidative effect through the restoration of mitochondrial function in RP is ongoing.
